These scientists used CRISPR to put an alligator gene into catfish

The resulting fish appear to be more resistant to disease and could improve commercial production—should they ever be approved.

Millions of fish are farmed in the US every year, but many of them die from infections. In theory, genetically engineering fish with genes that protect them from disease could reduce waste and help limit the environmental impact of fish farming. A team of scientists have attempted to do just that—by inserting an alligator gene into the genomes of catfish.

Americans go through a lot of catfish. In 2021, catfish farms in the US produced 307 million pounds (139 million kilogram) of the fish. “On a per-pound basis, anywhere from 60 to 70% of US aquaculture is … catfish production,” says Rex Dunham, who works on the genetic improvement of catfish at Auburn University in Alabama.

But catfish farming is also a great breeding ground for infections. From the time farmed fish are newly hatched to the time they are harvested, around 40% of the animals worldwide die from various diseases, says Dunham.

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